Features of coronary pathology and its relationship with myocardial fibrosis markers in patients with resistant hypertension

Aim. To evaluate the severity of coronary atherosclerosis and its association with biochemical markers fibrosis in patients artery disease (CAD) resistant hypertension (RHT). Material methods . The study included 39 CAD RHT. All underwent 24-hour blood pressure (BP) monitoring, office BP numbers were measured. Laboratory diagnostics routine tests, as well determination serum lipocalin, plasma concentration matrix metalloproteinases 2 9 (­MMP-2, MMP-9), tissue inhibitor metalloproteinases-1 (TIMP 1). Coronary was assessed retrospectively according to medical records an assessment protocols invasive angiography multislice computed tomography, performed no more than a year ago from moment inclusion clinical signs progression. Obstructive considered narrowing by 50%. Results. Considering results previous angiography, divided into two groups. In first group (n=20), stenosis <50%, second (n=19) >50% (p<0,05). compared groups comparable sex, age, duration hypertension, level, number antihypertensive drugs taken. There differences lipid profile, basal glycemia, uric acid levels, frequency cerebral accidents. However, incidence diabetes significantly higher Additionally, there significant difference levels lipocalin MMP-2 values these indicators (p=0,02). Conclusion. RHT symptoms myocardial ische­­mia, obstructive is Diabetes this category indicates frequent obstruction bed. An increase level associated severe damage can be indirect indicator atherosclerosis.